HCAI/II-IN-8
HCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I) ; 7.12 ± 0.12 nM (hCA II) ) . hCAI/II-IN-8 inhibits AChE and BChE as well (IC50 = 46.27 ±0.75 nM (AChE) ; 43.38 ± 0.83 nM (BChE) ) . [1].[1].
Product Specifications
CAS Number
3036136-18-9
UNSPSC
12352005
Target
Carbonic Anhydrase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hcai-ii-in-8.html
Solubility
10 mM in DMSO
Smiles
CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1
Molecular Formula
C22H20N4O3
Molecular Weight
388.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; CA II; CA I
Frequently Asked Questions
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