LgtC (N. meningitidis) Glycosyltransferase

<strong>LgtC (N. meningitidis) Glycosyltransferase</strong>_x000D_ <strong>Catalog number:</strong> B2016801_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 U_x000D_ <strong>Molecular Weight or Concentration:</strong> 33.4 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Lipopolysaccharyl α-galactosyltransferase, Lipopolysaccharyl-1,4-galactosyltransferase_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Xu Y, Cuccui J, Denman C, Maharjan T, Wren BW, Wagner GK. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC Bioorg Med Chem. 2018 Jul 15;26(11):2973-2983._x000D_ 2: Xu Y, Uddin N, Wagner GK. Covalent Probes for Carbohydrate-Active Enzymes: From Glycosidases to Glycosyltransferases Methods Enzymol. 2018;598:237-265._x000D_ 3: Persson K, Ly HD, Dieckelmann M, Wakarchuk WW, Withers SG, Strynadka NC. Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs Nat Struct Biol. 2001 Feb;8(2):166-75._x000D_ 4: Chan PH, Weissbach S, Okon M, Withers SG, McIntosh LP. Nuclear magnetic resonance spectral assignments of α-1,4-galactosyltransferase LgtC from Neisseria meningitidis: substrate binding and multiple conformational states Biochemistry. 2012 Oct 16;51(41):8278-92._x000D_ 5: Snajdrová L, Kulhánek P, Imberty A, Koca J. Molecular dynamics simulations of glycosyltransferase LgtC Carbohydr Res. 2004 Apr 2;339(5):995-1006._x000D_ 6: Kato T, Oizumi T, Ogata M, Murakawa A, Usui T, Park EY. Novel enzymatic synthesis of spacer-linked P(k) trisaccharide targeting for neutralization of Shiga toxin J Biotechnol. 2015 Sep 10;209:50-7._x000D_ 7: Tvaroska I. Molecular modeling insights into the catalytic mechanism of the retaining galactosyltransferase LgtC Carbohydr Res. 2004 Apr 2;339(5):1007-14._x000D_ 8: Métier CC, Wagner GK. Novel disaccharide inhibitors for the bacterial galactosyltransferase LgtC: Design, synthesis via Heyns rearrangement, and biochemical evaluation Carbohydr Res. 2020 Jun;492:108017._x000D_ 9: Chan PH, Cheung AH, Okon M, Chen HM, Withers SG, McIntosh LP. Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy Biochemistry. 2013 Jan 15;52(2):320-32._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28462843">10: Xu Y, Smith R, Vivoli M, Ema M, Goos N, Gehrke S, Harmer NJ, Wagner GK. Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases Bioorg Med Chem. 2017 Jun 15;25(12):3182-3194. </a>_x000D_ _x000D_ <strong>Products Related to LgtC (N. meningitidis) Glycosyltransferase can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>