PR280
PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) (IC50=700 nM) . PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide (dhCer) to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroceramide Desaturase 1 (DES1)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pr280.html
Smiles
CCCCCCCC(N[C@H]([C@@H](C1=C(C1=O)CCCCCCCCCCCCC)O)CO)=O
Molecular Formula
C27H49NO4
Molecular Weight
451.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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