(E) -Methyl 3,4,5-trimethoxycinnamate

(E) -Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E) -Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E) -Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes[1][2].

Product Specifications

CAS Number

[20329-96-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-methyl-3-4-5-trimethoxycinnamate.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)/C=C/C1=CC(OC)=C(OC)C(OC)=C1

Molecular Formula

C13H16O5

Molecular Weight

252.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Olajide OA, et al. Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. Inflammopharmacology. 2020 Oct;28 (5) :1315-1326. |[2]Zhao Z, et al. Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. Biol Pharm Bull. 2013;36 (2) :238-44.