AR antagonist 3
AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC50 of 0.47 μM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC50= 18.05 μM) . AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally[1].
Product Specifications
CAS Number
349573-58-6
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-3.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(S(=O)(NC1=CC=C(C=C1)OCC2=CC=CC=C2)=O)C
Molecular Formula
C15H18N2O3S
Molecular Weight
306.38
References & Citations
[1]Chai X, et al. Discovery of N- (4- (Benzyloxy) -phenyl) -sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2. J Med Chem. 2022, 65 (3) :2507-2521.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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