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DCB

DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) . DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) [1].

Product Specifications

CAS Number

6971-97-7

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H318, H335, H400, H410

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/dcb.html

Purity

98.81

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC(/C=N/N=C/C2=CC=CC(Cl)=C2)=CC=C1

Molecular Formula

C14H10Cl2N2

Molecular Weight

277.15

Precautions

H302, H315, H317, H318, H335, H400, H410

References & Citations

[1]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64 (3) :731-40.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 4

Isoform

MGluR5

Available Sizes

Frequently Asked Questions

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