Latent TGF beta 1/TGFB1, Cynomolgus (C33S, HEK293, His)
Latent TGF beta 1/TGFB1 Protein is a large extracellular matrix protein and an associated ligand of fibrillinmicrofibrils. Latent TGF beta 1/TGFB1 Protein, Cynomolgus (C33S, HEK293, His) is a recombinant protein (L30-S390, C33S) produced by HEK293 cells with His tag[1][2].
Product Specifications
Product Name Alternative
Latent TGF beta 1/TGFB1 Protein, Cynomolgus (C33S, HEK293, His), Cynomolgus, HEK293
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/latent-tgf-beta-1-tgfb1-protein-cynomolgus-c33s-hek293-his.html
Purity
90.0
Smiles
LSTSKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSKDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Molecular Formula
102129546 (Gene_ID) XP_005589396.1 (L30-S390, C33S) (Accession)
Molecular Weight
Approximately 50-60 kDa (precursorproprotein) & 38-45 kDa (LAP) & 13 kDa (TGFB1), based on SDS-PAGE under reducing conditions, due to the glycosylation.
References & Citations
[1]J Taipale, et al. Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein. J Cell Biol. 1994 Jan;124 (1-2) :171-81.|[2]C Unsöld, et al. Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains. J Cell Sci. 2001 Jan;114 (Pt 1) :187-197. |[3]Matthias Przyklenk, et al. LTBP1 promotes fibrillin incorporation into the extracellular matrix. bioRxiv. 2022.|[4]Rui Cai, et al. LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation. J Transl Med. 2020 Mar 26;18 (1) :139.|[5]Xiaojun Fu, et al. LTBP1 plays a potential bridge between depressive disorder and glioblastoma. J Transl Med. 2020 Oct 15;18 (1) :391.
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Storage Conditions
Stored at -20°C for 2 years
Scientific Category
Recombinant Proteins
Available Sizes
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