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Levomepromazine (maleate)

Levomepromazine maleate (Methotrimeprazine maleate) is an N-substituted phenylthiazine antipsychotic sedative that blocks multiple receptors. Levomepromazine maleate is a potent inhibitor of CYP2D6 and is useful in the study of schizophreni[1][2].

Product Specifications

CAS Number

7104-38-3

Product Name Alternative

Methotrimeprazine (maleate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Autophagy; Calcium Channel; Cytochrome P450; Dopamine Receptor; Enterovirus; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/levomepromazine-maleate.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O

Molecular Formula

C23H28N2O5S

Molecular Weight

444.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Gál G T, et al. Crystal structure of levomepromazine maleate[J]. Acta Crystallographica Section E: Crystallographic Communications, 2016, 72 (5) : 612-615.|[2]Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16 (1) :185-217.|[3]Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55 (5) :437-41.|[4]Gram LF, et al. Citalopram: interaction studies with levomepromazine, imipramine, and lithium. Ther Drug Monit. 1993 Feb;15 (1) :18-24.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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