PROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways, IC50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656) ; Blue, E3 (HY-W023573) ; Black, linker (HY-168552) ) [1].
Product Specifications
UNSPSC
12352211
Target
Anaplastic lymphoma kinase (ALK) ; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-alk-degrader-3.html
Smiles
CC1=C(C=C(C(NC2=NC=C(C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)Cl)=C1)OC(C)C)C4CCN(CC4)C5CN(C5)C6CCC(CC6)NC7=CC=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O
Molecular Formula
C50H60ClN9O7S
Molecular Weight
966.59
References & Citations
[1]Zhou H, et al. Discovery of orally bioavailable ALK PROTACs based ceritinib against ALK positive cancers. Eur J Med Chem. 2024 Dec 5;279:116827.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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