PROTAC ALK degrader-3

PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways, IC50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656) ; Blue, E3 (HY-W023573) ; Black, linker (HY-168552) ) [1].

Product Specifications

UNSPSC

12352211

Target

Anaplastic lymphoma kinase (ALK) ; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-alk-degrader-3.html

Smiles

CC1=C(C=C(C(NC2=NC=C(C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)Cl)=C1)OC(C)C)C4CCN(CC4)C5CN(C5)C6CCC(CC6)NC7=CC=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O

Molecular Formula

C50H60ClN9O7S

Molecular Weight

966.59

References & Citations

[1]Zhou H, et al. Discovery of orally bioavailable ALK PROTACs based ceritinib against ALK positive cancers. Eur J Med Chem. 2024 Dec 5;279:116827.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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