Kalata B7
Kalata B7 is a cyclotide that can be isolated from Oldenlandia affinis DC (Rubiaceae) and possesses membrane-permeating capabilities. Kalata B7 is also a partial agonist of oxytocin and vasopressin V1a receptors[1][2].
Product Specifications
CAS Number
339532-29-5
UNSPSC
12352209
Target
Oxytocin Receptor; Vasopressin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kalata-b7.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@](C(N[C@@](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@]4([H])CSSC[C@@]5([H])C(N[C@@](C(N[C@](CSSC[C@@](NC([C@](NC([C@@H](NC(CNC4=O)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)([H])C(N[C@@](C(N[C@H](C(NCC(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@H](C(NCC(N5)=O)=O)CCC(N)=O)=O)([H])[C@H](O)C)=O)CC6=CC=C(C=C6)O)=O)([H])CSSC2)=O)([H])[C@H](O)C)=O)=O)CC(C)C)=O)([H])[C@H](O)C)=O)([H])C(N[C@H](C(N7)=O)CO)=O)=O)([H])[C@H](O)C)=O)=O)C(C)C)=O)=O)CC(C)C)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)([H])[C@@H](C)CC)=O)([H])CCC1)[C@@H]7CC8=CNC9=CC=CC=C89
Molecular Formula
C128H196N36O40S6
Molecular Weight
3071.53
References & Citations
[1]Strömstedt AA, et al. Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. Biochim Biophys Acta. 2016;1858 (6) :1317-1327.|[2]Taghizadeh MS, et al. Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor. Sci Rep. 2022 Jun 2;12 (1) :9215.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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