INCB13739

INCB13739 is an orally active, potent, selective and tissue-specific11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor, with IC50 values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC), respectively. INCB13739 can be used for type 2 diabetes mellitus (T2DM) and obesity research[1].

Product Specifications

CAS Number

[869974-19-6]

UNSPSC

12352005

Target

11β-HSD; Glucocorticoid Receptor; Mineralocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/incb13739.html

Purity

99.77

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=C(C2=CC=C(C3(C(N4C[C@]5(CC4)OC(C6=C5C=CC=C6)=O)=O)CC3)C=C2)C=C1)NC

Molecular Formula

C28H25N3O4

Molecular Weight

467.52

References & Citations

[1]Marando C, et al. Discovery of 1'- (1-phenylcyclopropane-carbonyl) -3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach. Bioorg Med Chem Lett. 2022 Aug 1;69:128782.