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BQ7859

BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) [1]. BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

Product Specifications

UNSPSC

12352209

Target

PSMA; Radionuclide-Drug Conjugates (RDCs)

Type

Peptides

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bq7859.html

Smiles

O=C(CN1CCN(CCN(CC1)CC(O)=O)CC(NCCCC[C@H](NC(C)=O)C(NCCCCCCCC(N[C@H](C(N[C@H](C(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC2=CC3=C(C=C2)C=CC=C3)=O)CC4=CC=C(O)C=C4)=O)=O)=O)O

Molecular Formula

C62H89N11O18

Molecular Weight

1276.43

References & Citations

[1]Abouzayed A, et al. 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry. Front Oncol. 2023 Sep 27;13:1221103.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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