Hexa-D-arginine (TFA)

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

Product Specifications

CAS Number

[958204-56-3]

Product Name Alternative

Furin Inhibitor II (TFA)

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hexa-d-arginine-tfa.html

Purity

98.42

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C38H76F3N25O8

Molecular Weight

1068.17

References & Citations

[1]Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70 (12) :7136-9.|[2] Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72 (1) :602-5.|[3]Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275 (47) :36741-9.