MB-07344
MB-07344 is a potent thyroid hormone receptor (TR) -β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys[1].
Product Specifications
CAS Number
852947-39-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/mb-07344.html
Purity
99.86
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC1=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=CC(OCP(O)(O)=O)=C1
Molecular Formula
C19H25O5P
Molecular Weight
364.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156 (3) :454-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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