MB-07344

MB-07344 is a potent thyroid hormone receptor (TR) -β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1].

Product Specifications

CAS Number

[852947-39-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/mb-07344.html

Purity

99.86

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC1=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=CC(OCP(O)(O)=O)=C1

Molecular Formula

C19H25O5P

Molecular Weight

364.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156 (3) :454-65.