PAR4 antagonist 2
PAR4 antagonist 2 (Compound 31) is a protease activated receptor 4 (PAR4) antagonist, with IC50 values of 95 nM and 367 nM for human PAR4 and mouse PAR4. PAR4 antagonist 2 is active against PAR4 activation by the native protease thrombin cleavage but not the synthetic PAR4 agonist peptide AYPGKF[1].
Product Specifications
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NNC(C2=C(F)C=C(F)C=C2)=N1)C3=NN(C4=CC=CC=C4)C5=C3CCCC5
Molecular Formula
C22H18F2N6O
Molecular Weight
420.41
References & Citations
[1]Smith ST, et al. Discovery of Protease-Activated Receptor 4 (PAR4) -Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacol Transl Sci. 2024 Mar 21;7 (4) :1086-1100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR4
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