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PAR4 antagonist 2

PAR4 antagonist 2 (Compound 31) is a protease activated receptor 4 (PAR4) antagonist, with IC50 values of 95 nM and 367 nM for human PAR4 and mouse PAR4. PAR4 antagonist 2 is active against PAR4 activation by the native protease thrombin cleavage but not the synthetic PAR4 agonist peptide AYPGKF[1].

Product Specifications

UNSPSC

12352005

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/par4-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NNC(C2=C(F)C=C(F)C=C2)=N1)C3=NN(C4=CC=CC=C4)C5=C3CCCC5

Molecular Formula

C22H18F2N6O

Molecular Weight

420.41

References & Citations

[1]Smith ST, et al. Discovery of Protease-Activated Receptor 4 (PAR4) -Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacol Transl Sci. 2024 Mar 21;7 (4) :1086-1100.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAR4

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