(R)-Azetidine-2-carboxylic acid
Product Specifications
UNSPSC Description
(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-azetidine-2-carboxylic-acid.html
Purity
99.86
Solubility
H2O : ≥ 175 mg/mL
Smiles
O=C([C@@H]1NCC1)O
Molecular Weight
101.10
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W017755/R-Azetidine-2-carboxylic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W017755/R-Azetidine-2-carboxylic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7729-30-8
Available Sizes
Curated Selection
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