(R) -Azetidine-2-carboxylic acid
Selected Variant
HY-W017755-01
Size: 1 g
(R) -Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . (R) -Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
Product Specifications
CAS Number
7729-30-8
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-azetidine-2-carboxylic-acid.html
Purity
99.86
Solubility
H2O : ≥ 175 mg/mL
Smiles
O=C([C@@H]1NCC1)O
Molecular Formula
C4H7NO2
Molecular Weight
101.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
Price
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