(-) -Huperzine A-d4 (hydrochloride)

(-) -Huperzine A-d4 hydrochloride is deuterated labeled (-) -Huperzine A (HY-17387) . (-) -Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-) -Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-) -Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-) -Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].

Product Specifications

Product Name Alternative

Huperzine A-d4

UNSPSC

12352005

Target

Apoptosis; Cholinesterase (ChE) ; iGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C([C@@](/C3=C([2H])\C([2H])([2H])[2H])(N)CC(C)=C[C@@]3([H])C2)C=C1.Cl

Molecular Formula

C15H15D4ClN2O

Molecular Weight

282.80

References & Citations

[1]MA Xiao-Chao, XIN Jian, WANG Hai-Xue, et al. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol ogica Sinica, 2003, 24 (3) :247-250.|[2]Rui Wang, et al. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27 (1) :1-26.|[3]J M Zhang, et al. Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.Neuroscience. 2001;105 (3) :663-9|[4]Maung Kyaw Moe Tun, et al. The pharmacology and therapeutic potential of (−) -huperzine A. J Exp Pharmacol. 2012; 4: 113–123.|[5]R Wang, et al. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein- (1-40) in rat. Eur J Pharmacol. 2001 Jun 15;421 (3) :149-56.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.