Recombinant Human/Murine/Rat Activin A

Activins and Inhibins are TGF- beta; superfamily cytokines that are involved in tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin A protects the heart from hypoxic stress and promotes the differentiation of embryonic stem cells into cardiomyocytes. Activins are homodimers or heterodimers of various beta; subunits (beta; A, beta; B, beta; C, and beta; E), while Inhibins are heterodimers of a unique alpha; subunit and one of the beta; subunits. Activin A is a homodimer of two beta; A chains. Human beta; A shares 100% amino acid sequence identity with mouse, rat, bovine, porcine, and feline beta; A. Activin A binds to Activin RIIA which then associates with Activin RIB/ALK-4. Activin A bioactivity is regulated by cell-associated molecules (BAMBI, Betaglycan, and Cripto) and soluble molecules (beta;2-Macroglobulin, Follistatin, and FLRG) .

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Apparent molecular mass of 24 kDa in SDS-PAGE under non-reducing conditions, 14 kDa under reducing conditions, a disulfide-linked homodimer of two 116 amino acid glycosylated polypeptide chains.