LUF6283

LUF6283 is a potent and orally active HCA (2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1].

Product Specifications

CAS Number

[92933-48-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Hydroxycarboxylic Acid Receptor (HCAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/luf6283.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NNC(CCCC)=C1)O

Molecular Formula

C8H12N2O2

Molecular Weight

168.20

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Li Z, et al. Effects of pyrazole partial agonists on HCA (2) -mediated flushing and VLDL-triglyceride levels in mice. Br J Pharmacol. 2012 Oct;167 (4) :818-25.