SCH 51866

SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM) . SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension[1].

Product Specifications

CAS Number

[167298-74-0]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sch-51866.html

Smiles

CN1C2=N[C@](CCC3)([H])[C@]3([H])N2C4=C(C1=O)N=C(N4)CC5=CC=C(C=C5)C(F)(F)F

Molecular Formula

C19H18F3N5O

Molecular Weight

389.37

References & Citations

[1]Vemulapalli S, et al. Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor[J]. Journal of cardiovascular pharmacology, 1996, 28 (6) : 862-869.