ICI-63197

ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects[1][2].

Product Specifications

CAS Number

[27277-00-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ici-63197.html

Purity

99.14

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C1N(CCC)C2=NC(N)=NN2C=C1C

Molecular Formula

C9H13N5O

Molecular Weight

207.23

Precautions

H302, H315, H319, H335

References & Citations

[1]M Hoey, et al. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem Pharmacol. 1990 Jul 15;40 (2) :193-202. |[2]H Wachtel. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology. 1983 Mar;22 (3) :267-72.|[3]H Johnston, et al. Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alpha-adrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol. 1986 Mar;87 (3) :553-62.