CP681301
CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells) . CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila[1].
Product Specifications
CAS Number
[865317-32-4]
UNSPSC
12352005
Target
CDK; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp681301.html
Purity
99.18
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(N(C)C)C=C3
Molecular Formula
C17H22N4O
Molecular Weight
298.38
References & Citations
[1]Mukherjee S, et al. CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. Cell Rep. 2018 May 8;23 (6) :1651-1664.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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