CP681301

CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells) . CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila[1].

Product Specifications

CAS Number

[865317-32-4]

UNSPSC

12352005

Target

CDK; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cp681301.html

Purity

99.18

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(N(C)C)C=C3

Molecular Formula

C17H22N4O

Molecular Weight

298.38

References & Citations

[1]Mukherjee S, et al. CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. Cell Rep. 2018 May 8;23 (6) :1651-1664.