E-64
E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
Product Specifications
CAS Number
66701-25-5
Product Name Alternative
Proteinase inhibitor E 64
UNSPSC
12352005
Hazard Statement
H372
Target
Autophagy; Bacterial; Cathepsin
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/E-64.html
Purity
99.96
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)O
Molecular Formula
C15H27N5O5
Molecular Weight
357.41
Precautions
H372
References & Citations
[1]Matsumoto K, et al. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers. 1999;51 (1) :99-107.|[2]Wadhawan M, et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9 (3) :e93161.|[3]Baldzizhar R, et al. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem. 2013 Jan 18;288 (3) :1612-9.|[4]Blass G, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4 (17) . pii: e12950.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K; Cathepsin L
Available Sizes
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