Nutlin 1
Product Specifications
UNSPSC Description
Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM[1].
Target Antigen
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nutlin-1.html
Smiles
CC(N1CCN(CC1)C(N2[C@H]([C@H](N=C2C3=CC=C(C=C3OC(C)C)OC)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)=O)=O
Molecular Weight
609.54
References & Citations
[1]Lyubomir T Vassilev, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118542/Nutlin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118542/
Clinical Information
No Development Reported
CAS Number
548472-58-8
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