HSD17B13-IN-5
HSD17B13-IN-5 (Compound 96) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with a Ki value of ≤ 50 nM for the estradiol substrate LCMS. HSD17B13-IN-5 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) [1].
Product Specifications
UNSPSC
12352005
Target
17β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hsd17b13-in-5.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C2=NC(C(NCC3=C(C(F)(F)F)C=CC=C3)=O)=C(NC(C4=CC(F)=C(C(Cl)=C4)O)=O)S2)=CC=C1
Molecular Formula
C26H15ClF4N4O3S
Molecular Weight
574.93
References & Citations
[1]Joshua Odingo, et al. 2-substituted thiazole hsd17b13 inhibitors and uses thereof. WIPO, WO2023146897. 2023-08-03.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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