EGFR-IN-116

EGFR-IN-116 (compound 14D) is an anticancer agent. EGFR-IN-116 against EGFR has the IC50 valuesof EGFR, VEGFR-2 and Topo II are 0.103 μM, 0.069 μM and 19.74 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

EGFR; Topoisomerase; VEGFR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-116.html

Smiles

O=C(NC1=CC=C(C)C=C1)CN2N=NC(CSC(N3C4=CC=CC=C4)=NC5=C(C=CC=C5)C3=O)=C2

Molecular Formula

C26H22N6O2S

Molecular Weight

482.56

References & Citations

[1]El Hamaky NFM, et al. Novel quinazolin-2-yl 1,2,3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study. Bioorg Chem. 2024 Jul;148:107437.