SIRT3 activator 1

SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases[1].

Product Specifications

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sirt3-activator-1.html

Concentration

10mM

Purity

98.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@]([H])([C@@](C)(CCC2)C(N3CCN(CC3)C(C4=CC=CC=C4C(O[Na])=O)=O)=O)CC[C@]5([C@]1(CC[C@]6(C5)C)[H])CC6=O

Molecular Formula

C32H41N2NaO5

Molecular Weight

556.67

References & Citations

[1]Chen Z, et al. Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects. J Med Chem. 2024 Apr 25;67 (8) :6749-6768.