Agaric acid

Agaric acid (Agaricinic Acid) is an orally active inhibitor of adenine nucleotide translocase found in specific fungi. Agaric acid can inhibit the biofilm formation of various bacteria such as Salmonella. Agaric acid can also induce mitochondrial permeability transition, prompting mitochondria to release Ca2+, disrupting the transmembrane potential, and causing mitochondrial swelling. In addition, Agaric acid can also inhibit citrate transport in liver mitochondria and participate in the inhibition of fatty acid synthesis, affecting multiple metabolic processes[1][2][3][4].

Product Specifications

CAS Number

[666-99-9]

Product Name Alternative

Agaricinic Acid

UNSPSC

12352211

Target

Bacterial; Calcium Channel; Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/agaric-acid.html

Purity

99.45

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCCC(C(O)=O)C(C(O)=O)(O)CC(O)=O

Molecular Formula

C22H40O7

Molecular Weight

416.55

References & Citations

[1]García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5 (4) :272-81.|[2]Freedland RA, et al. Agaric acid. Methods Enzymol. 1981;72:497-506.|[3]Lories B, et al. Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility. Biofilm. 2020 May 29;2:100022.|[4]Chávez E, et al. The effect of agaric acid on citrate transport in rat liver mitochondria. Life Sci. 1978 Oct 9;23 (14) :1423-9.