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Artemotil

Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys[1][2].

Product Specifications

CAS Number

75887-54-6

Product Name Alternative

β-Arteether; (+) -Arteether; Arteether

UNSPSC

12352005

Hazard Statement

H361

Target

CXCR; Parasite

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Artemotil.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@H]1[C@@](CC[C@@H](C)[C@]2([H])CC[C@]3(C)O4)([H])[C@@]2(OO3)[C@]4([H])O[C@@H]1OCC

Molecular Formula

C17H28O5

Molecular Weight

312.40

Precautions

H361

References & Citations

[1]Shmuklarsky MJ, et al. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg. 1993 Mar;48 (3) :377-84.|[2]Li QG, et al. Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24 (3) :213-23.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Plasmodium

Available Sizes

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