STF-62247
STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively) [1].
Product Specifications
CAS Number
[315702-99-9]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/STF-62247.html
Purity
98.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1
Molecular Formula
C15H13N3S
Molecular Weight
267.35
Precautions
H302, H319
References & Citations
[1]Turcotte, S. et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer cell 14, 90-102, doi:10.1016/j.ccr.2008.06.004 (2008)
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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