PDL1 degrader-1
PDL1 degrader-1 (compound PMT-O9-1A) is a potent PD-L1 degrader. PDL1 degrader-1 decreases the protein expression of PD-L1. PDL1 degrader-1 shows cytotoxicity. PDL1 degrader-1 shows anticancer activity[1].
Product Specifications
UNSPSC
12352211
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pmt-o9-1a.html
Purity
95.25
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(C2=C[N+]3=C(C4=CC(OC)=C(C=C4CC3)OC)C=C2C=C1)OCCN.[Cl-]
Molecular Formula
C22H25ClN2O4
Molecular Weight
416.90
References & Citations
[1]Zeng Z, et al. Advancing Cancer Immunotherapy through Engineering New PD-L1 Degraders: A Comprehensive Study from Small Molecules to PD-L1-Specific Peptide-Drug Conjugates. J Med Chem. 2024 Oct 18.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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