Sigma-1 receptor antagonist 6
Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be used in neuropathic pain animal models to alleviate mechanical allodynia induced by paclitaxel.
Product Specifications
CAS Number
1335032-28-4
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sigma-1-receptor-antagonist-6.html
Smiles
C#CCN(C)C1=NC(NCCCC2CCN(CC3=CC=CC=C3)CC2)=C(C#N)C(C4=CC=CC=C4)=C1C#N
Molecular Formula
C32H34N6
Molecular Weight
502.65
References & Citations
[1]Entrena JM, et al. The proof of concept of 2-{3-[N- (1-benzylpiperidin-4-yl) propyl]amino}-6-[N-methyl-N- (prop-2-yn-1-yl) amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain. Bioorg Chem. 2024 Sep;150:107537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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