SH-E4A-66
SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide) . SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 μM) [1].
Product Specifications
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sh-e4a-66.html
Smiles
O=C(N1C(C=CC=C2)=C2C3=C1C=CC=C3)C4=CC(NC(C=C)=O)=CC(NC(CCl)=O)=C4
Molecular Formula
C24H18ClN3O3
Molecular Weight
431.87
References & Citations
[1]Yang D, et al. Systematic Targeting of Protein Complexes with Molecular COUPLrs[J]. bioRxiv, 2024: 2024.07. 16.603666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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