PROTAC HDAC8 Degrader-2
Product Specifications
UNSPSC Description
PROTAC HDAC8 Degrader-2 (compound 32a) is a degrader of HDAC8 with a DC50 of 8.9 nM and HDAC6 with a DC50 of 14.3 nM. PROTAC HDAC8 Degrader-2 is composed of PROTAC target protein ligand HDAC8 ligand 1 (HY-168176) (red part), E3 ligase ligand Thalidomide-4-OH (HY-103596) (blue part) and PROTAC Linker 1,5-Diaminopentane (HY-W540541) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C5-NH2 (HY-134986)[1].
Target Antigen
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-hdac8-degrader-2.html
Smiles
O=C(C1=CN=C(N2CCN(CC3=CN(C)C4=C3C=C(OCC(NCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)C=C4)CC2)N=C1)NO
Molecular Weight
780.83
References & Citations
[1]Hany S Ibrahim, et al. Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders. Bioorg Chem. 2024 Oct 12:153:107887.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168175/PROTAC-HDAC8-Degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168175/
Clinical Information
No Development Reported
Curated Selection
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