Human β-defensin-1

Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria[1].

Product Specifications

CAS Number

[452274-53-2]

Product Name Alternative

HβD-1

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/human-β-defensin-1.html

Purity

99.33

Smiles

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H]3NC4=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H]4CCCCN)=O)=O)=O)=O)=O)=O)NC6=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(O)=O)=O)NC3=O)C(N8[C@@H](CCC8)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@H]6[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

Molecular Formula

C167H256N48O50S6

Molecular Weight

3928.53

References & Citations

[1]Judith Raschig, et al. Ubiquitously Expressed Human Beta Defensin 1 (hBD1) Forms Bacteria-Entrapping Nets in a Redox Dependent Mode of Action. PLoS Pathog. 2017 Mar 21;13 (3) :e1006261.|[2]E V Valore, et al. Human beta-defensin-1: An Antimicrobial Peptide of Urogenital Tissues.J Clin Invest. 1998 Apr 15;101 (8) :1633-42.