Picraline

Picraline is a natural alkaloid that targets opioid receptors with binding affinities with Ki values of 132 μM, 2.38 μM and 98.8 μM for μOR, κOR and δOR, respectively[1].

Product Specifications

CAS Number

[2671-32-1]

UNSPSC

12352005

Target

Opioid Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/picraline.html

Solubility

10 mM in DMSO

Smiles

CC(OC[C@]([C@]1(C2=CC=CC=C2N3)[C@@]3(O4)[C@@]5([H])N(C/6)[C@]4([H])C1)([C@@](C6=C/C)([H])C5)C(OC)=O)=O

Molecular Formula

C23H26N2O5

Molecular Weight

410.46

References & Citations

[1]Simone M Creed, et al. Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. J Nat Prod. 2021 Jan 22;84 (1) :71-80.