CAY10506
Product Specifications
UNSPSC Description
CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research[1].
Target Antigen
Apoptosis; PPAR
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cay10506.html
Solubility
10 mM in DMSO
Smiles
O=C1SC(CC2=CC=C(C=C2)OCCNC(CCCCC3SSCC3)=O)C(N1)=O
Molecular Weight
454.63
References & Citations
[1]Han EJ, et al. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPARγ-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell lung cancer cells. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):e239-48.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118988/CAY10506-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118988/
Clinical Information
No Development Reported
CAS Number
292615-75-9
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