CAY10506

CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research[1].

Product Specifications

CAS Number

[292615-75-9]

UNSPSC

12352005

Hazard Statement

H225-H302-H319-H336

Target

Apoptosis; PPAR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cay10506.html

Solubility

10 mM in DMSO

Smiles

O=C1SC(CC2=CC=C(C=C2)OCCNC(CCCCC3SSCC3)=O)C(N1)=O

Molecular Formula

C20H26N2O4S3

Molecular Weight

454.63

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Han EJ, et al. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPARγ-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell lung cancer cells. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85 (5) :e239-48.