PROTAC SMARCA2/4-degrader-28
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of SMARCA2 and SMARCA4 (Bliue: CRL2VHL ligand (S, R, S) -AHPC ; Black: linker (HY-159680) ; Pink: a SMARCA-BD ligand (+) -JQ-1 (HY-13030) ).
Product Specifications
CAS Number
2409844-88-6
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-28.html
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N[C@@H]4COCCOCCOC5=CC(C6=C(N=CS6)C)=CC=C5CNC([C@@]7([H])N(C[C@@H](C7)O)C([C@@H](NC(COCCOCCOC4)=O)C(C)(C)C)=O)=O)=O)C8=NN=C(C)N28
Molecular Formula
C54H68ClN9O11S2
Molecular Weight
1118.75
References & Citations
[1]Angus D Cowan, et al. Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. Annu Rev Biochem. 2022 Jun 21:91:295-319.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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