6-Hydroxyflavanone

6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes[1][2].

Product Specifications

CAS Number

[4250-77-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX; GABA Receptor; Lipoxygenase; Opioid Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-hydroxyflavanone.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1)C(C=C(O)C=C2)=C2OC1C3=CC=CC=C3

Molecular Formula

C15H12O3

Molecular Weight

240.25

Precautions

H315, H319, H335

References & Citations

[1]Zolkeflee NKZ, et al. In Vitro Anti-Diabetic Activities and UHPLC-ESI-MS/MS Profile of Muntingia calabura Leaves Extract. Molecules. 2022 Jan 4;27 (1) :287.|[2]Akbar S, et al. Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone. Nutrients. 2023 May 30;15 (11) :2552.