Etavopivat
Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies[1][2].
Product Specifications
CAS Number
[2245053-57-8]
Product Name Alternative
FT-4202
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/etavopivat.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(N1CC2=C(CN(C2)C([C@@H](C3=CC=CC=C3)CO)=O)C1)(C4=CN=C(OCCO5)C5=C4)=O
Molecular Formula
C22H23N3O6S
Molecular Weight
457.50
References & Citations
[1]Shrestha A, et al. FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. Blood Adv. 2021 May 11;5 (9) :2385-2390.|[2]Schroeder P, et al. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 Mar;380 (3) :210-219.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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