GNE-987 GSH linker-1
GNE-987 GSH linker-1 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker[1].
Product Specifications
CAS Number
2417370-39-7
UNSPSC
12352005
Target
PROTAC-Linker Conjugates for PAC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-for-pac-1.html
Purity
98.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCCCCCCCCCNC(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)=O)N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O
Molecular Formula
C62H77F2N9O12S4
Molecular Weight
1306.58
References & Citations
[1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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