Triphenyl phosphate

Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and tumor necrosis factor α. Triphenyl phosphate can also cause allergic contact dermatitis[1][2].

Product Specifications

CAS Number

[115-86-6]

UNSPSC

12352005

Hazard Statement

H302, H361, H372, H410

Target

Interleukin Related; Monoamine Oxidase; NF-κB; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/triphenyl-phosphate.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=P(OC1=CC=CC=C1)(OC2=CC=CC=C2)OC3=CC=CC=C3

Molecular Formula

C18H15O4P

Molecular Weight

326.28

Precautions

H302, H361, H372, H410

References & Citations

[1]Xiaoxun Lu, et al. Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. Sci Total Environ. 2023 Dec 15:904:166688.|[2]J G Camarasa, et al. Allergic contact dermatitis from triphenyl phosphate. Contact Dermatitis. 1992 Apr;26 (4) :264-5.