Anti-tsp23 Antibody

Mouse Monoclonal Antibody specific to tsp23

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-tsp23 Mouse Monoclonal Antibody

Gene Name

PTGES3L

Gene ID

80755

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=PTGES3L">PTGES3L</a>

UniProt

B9A003

Accession Number

NP_001136126.1

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Recombinant tsp23

Target Antigen

Putative protein PTGES3L

Target

tsp23

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, AM

Field of Research

Heat Shock& Stress Proteins

Purification Method

Purified by Protein G affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Immunoblotting: use at 1ug/mL. A band of ~19kDa is detected. These are recommended concentrations; Enduser should determine optimal concentrations for their applications. Positive control: Lysate of HeLa cells transiently transfected with Tsp23.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human and mouse tsp23. Other species have not been investigated. It does not cross-react with p23.

Formulation

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.Purified by Protein G affinity chromatography.

Buffer pH

pH 7.4

Target Background

tsp23 (transcript similar p23) is a homolog of human p23, a highly conserved ubiquitous protein and a cochaperone for the Hsp90 chaperone system. A small protein (18-25kDa) with a simple structure, p23 is a highly acidic phosphoprotein with an aspartic acid- rich C-terminal domain. Although numerous studies have found p23 associated with other proteins (i.e, Fes tyrosine kinase, heme regulated kinase HRI, Hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase), the functional significance of p23 remains to be clearly defined. It appears to be involved in ATP-mediated Hsp90 binding of client proteins. A recent study suggests that p23 might be a promising target in leukemic apoptosis. tsp23 is 44% homologous with p23.