Cholic acid 7-sulfate

Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1) . As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation[1][2].

Product Specifications

CAS Number

[60320-05-0]

Product Name Alternative

7-Sulfocholic acid

UNSPSC

12352211

Target

G protein-coupled Bile Acid Receptor 1; MHC

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cholic-acid-7-sulfate.html

Purity

99.92

Solubility

DMF : 1 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL

Smiles

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](OS(=O)(O)=O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C

Molecular Formula

C24H40O8S

Molecular Weight

488.63

References & Citations

[1]Chaudhari SN, et, al. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 Jan;17 (1) :20-29.|[2]Ito E, et al. Sulfated bile acid is a host-derived ligand for MAIT cells. Sci Immunol. 2024 Jan 26;9 (91) :eade6924.