Anticancer agent 221
Product Specifications
UNSPSC Description
Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-221.html
Smiles
O=C(NC1=CC2=C(C=C1)C(C=C(C(F)(F)F)O2)=O)C3=CC=C(F)C=C3
Molecular Weight
351.25
References & Citations
[1]Jorepalli S, et al., Synthesis, molecular docking studies and biological evaluation of N-(4-oxo-2-(trifluoromethyl)-4H-chromen-7-yl) benzamides as potential antioxidant, and anticancer agents. Sci Rep. 2024 Apr 29;14(1):9866.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163616/Anticancer-agent-221-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163616/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
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